Technology
At ArgusEye, we develop advanced biosensor technology for real-time bioprocess monitoring in biopharmaceutical development and manufacturing. Our platform is based on Localized Surface Plasmon Resonance (LSPR), an optical biosensing technology that enables real-time, label-free detection of biomolecules directly in complex bioprocess samples.
Built on more than 15 years of scientific research, our biosensor technology provides continuous insight into critical process parameters (CPPs) and critical quality attributes (CQAs) without the delays associated with traditional laboratory analysis.
Whether used in process development, optimization, or manufacturing, our biosensor technology enables real-time bioprocess analytical monitoring and smarter decision-making throughout the bioprocess workflow.
Biosensor technology combines biological recognition elements with a signal transducer to detect, measure, and monitor specific molecules. Biosensors are widely used across healthcare, diagnostics, life sciences, environmental monitoring, and biopharmaceutical manufacturing.
In bioprocessing, biosensor technology enables real-time monitoring of critical process parameters and quality attributes without the delays associated with traditional laboratory analysis.
Unlike conventional methods that rely on manual sampling and offline measurements, modern biosensor technologies provide continuous process insight directly where measurements are needed. This allows manufacturers to improve process understanding, optimize production, reduce delays, and support data-driven decision-making.
At ArgusEye, biosensor technology is the foundation of our Auga® platform, specifically designed for modern biopharmaceutical development and manufacturing.
Localized Surface Plasmon Resonance (LSPR) is a phenomenon that occurs when light interacts with metal nanoparticles, typically gold or silver, causing their electrons to oscillate in resonance with the light.
These oscillations are highly sensitive to changes in the local environment, such as the presence of biomolecules near the nanoparticle surface. This sensitivity allows our systems to detect tiny changes in refractive index as biomolecules bind to the surface.
No labels or fluorescent tags are needed, and binding events are detected directly, in real time, and with high precision.
By leveraging LSPR biosensor technology, ArgusEye delivers accurate and continuous monitoring of biomolecular interactions in complex bioprocess environments.
Unlike traditional analytical tools, our biosensors require no sample preparation, even in complex sample matrices, and can operate under ambient conditions. This is made possible through our flexible sensor systems, and robust sensor chips with proprietary surface chemistry optimized for reliable performance in demanding biopharmaceutical applications.
Our sensors for biopharma enable real-time monitoring of critical quality attributes (CQAs) and critical process parameters (CPPs) directly in upstream and downstream bioprocess streams.
Key Benefits Include:
Real-time, label-free detection of biomolecules
No sample prep required
Reliable performance in complex process media
Flexible sensor functionalization for specific targets
Scalable implementation from development to production
Support for Process Analytical Technology (PAT)
Compared with traditional analytical workflows, LSPR biosensors provide immediate access to critical process data while reducing dependency on time-consuming laboratory analysis.
The core of our technology is a nanopatterned sensor chip, where the resonance frequency of metal nanostructures shifts upon binding of target molecules.
These shifts are detected optically and translated into quantitative data in real time.
By functionalizing the sensor surface with capture molecules tailored to specific analytes, we can target product titer, contaminants, aggregates, or quality markers.
Our technology is implemented through advanced biosensor monitoring systems and specialized sensor chips, supporting continuous monitoring and seamless integration into bioprocess workflows.
Many analytical techniques rely on manual sampling and delayed laboratory results before process decisions can be made.
ArgusEye’s LSPR biosensor technology provides a different approach by delivering real-time process intelligence directly from the bioprocess environment.
By combining advanced optical sensing, robust surface chemistry, and flexible sensor design, ArgusEye enables reliable monitoring even in complex bioprocess conditions.
Whether you are exploring biosensor technology, implementing Process Analytical Technology (PAT), or looking for real-time monitoring solutions, our team can help.
Do you have questions about our products, applications or technology? Contact us using the form below and we will be sure to get back at you as soon as possible.
You can also email us at info@arguseyesensors.com
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